Fig. 2

The role of perivascular AQP4 in the clearance of extracellular solutes. (A) Snta1^–/– mice have severely attenuated level of AQP4 in endfeet due to the lack of α-syntrophin, which is an integral part of the anchoring of AQP4. (B) Clearance of intrastriatal [³H]mannitol in age-matched Snta1^–/– and WT mice 2 h after infusion. Average ± SD age: Snta1^–/– 95 ± 13 days, WT 93 ± 14 days. n = 12 mice per genotype. (C) Clearance of intrastriatal 500 kDa [³H]dextran in age-matched Snta1^–/– and WT mice 2 and 3 h after infusion. n = 8 for WT and n = 10 for Snta1^–/– at 2 h, n = 9 mice per genotype at 3 h. Average ± SD age: for 2 h – Snta1^–/– 120 ± 12 days, WT 124 ± 17 days; for 3 h – for Snta1^–/– 113 ± 22, for WT 122 ± 21. Data represented as mean ± s.e.m, * = p < 0.05, ** = p < 0.01, mixed effects linear regression model (see Materials and Methods)