Fig. 3

Clearance of extracellular solutes is size independent. Clearance of intrastriatal 0.18 kDa [³H]mannitol and 500 kDa [³H]dextran 2 h after infusion in (A) WT mice, average ± SD age: [³H]mannitol 95 ± 13 days, [³H]dextran 93 ± 14 days. (B) Aqp4^–/– mice that lack AQP4, average ± SD age: [³H]mannitol 95 ± 13 days, [³H]dextran 93 ± 14 days. and (C) Snta1^–/– mice which have have severely attenuated level of AQP4 in endfeet due to the lack of α-syntrophin, average ± SD age: [³H]mannitol 95 ± 13 days, [³H]dextran 93 ± 14 days. Data represented as mean ± s.e.m. WT: n = 20 mice per group; Aqp4^–/– mice: n = 8 for [³H]mannitol, n = 7 for [³H]dextran; Snta1^–/– mice: n = 12 for [³H]mannitol, n = 10 for [³H]dextran; unpaired two tailed t-test