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Fig. 2 | Fluids and Barriers of the CNS

Fig. 2

From: Choroid plexus enlargement in amyotrophic lateral sclerosis patients and its correlation with clinical disability and blood-CSF barrier permeability

Fig. 2

CP segmentation pipeline. (A) Using FreeSurfer, the lateral ventricle, inferior lateral ventricle, and CP regions in both the left and right cerebral hemispheres were extracted as the initial mask. (B) Bayesian Gaussian mixture models (GMMs) were used to cluster the initial mask into two groups: CSF voxels (low average intensity) and CP and lateral ventricle wall voxels (high average intensity. (C) SUSAN smoothing in FSL software was performed on the CP and lateral ventricle wall voxels. (D) GMMs were again used to cluster the smoothed voxels into three groups, and the group with the highest average intensity was considered the CP group. Each subject’s CP segmentation was further reviewed and manually corrected by two neuroradiologists, and the CP volume was extracted for further analysis

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Fluids and Barriers of the CNS

ISSN: 2045-8118