Table 1 Demographic and clinical features for ALS patients and HCs

Age (years)

57.1 ± 9.6

57.3 ± 7.9

0.88

Men/Women (n)

94/61

55/50

0.21

Education

9.4 ± 4.0

9.9 ± 3.2

0.26

ALS duration (month)

13.6 ± 7.9

-

-

Bulbar ALS onset n, (%)

39 (25.1)

-

-

ALSFRS-R scores

40.3 ± 3.7

-

-

Progression rate

0.78 ± 0.68

-

-

CP volume (mm³)

2930.7 ± 724.8

2454.5 ± 781.3

<0.01

Qalb (mg/g)

5.9 ± 2.8

-

-

HARS scores

8.7 ± 5.2

4.0 ± 3.9

<0.01

HDRS scores

10.5 ± 4.9

3.4 ± 4.2

<0.01