Table 2 Demographic and clinical information for patient subgroups and HCs
|  | Genetic ALS patients (n = 12) | Sporadic ALS patients (n = 143) | HCs (n = 105) | F or χ2 | P-value |
|---|---|---|---|---|---|
Age (years) | 44.5 ± 10.3 | 58.2 ± 8.7 | 57.3 ± 7.9 | 14.17 | <0.01 |
Men/Women (n) | 9/3 | 85/58 | 55/50 | 2.84 | 0.24 |
Education | 8.3 ± 3.3 | 9.5 ± 4.0 | 9.9 ± 3.2 | 1.23 | 0.29 |
ALS duration (month) | 14.5 ± 9.7 | 13.6 ± 6.0 | - | 0.37 | 0.71 |
Bulbar ALS onset n, (%) | 4 (33.3) | 34 (23.7) | - | 0.54 | 0.49 |
ALSFRS-R scores | 38.1 ± 6.1 | 40.5 ± 3.4 | - | 2.16 | 0.03 |
Progression rate | 0.75 ± 0.62 | 0.78 ± 0.69 | - | 0.13 | 0.89 |
CP volume (mm3) | 3161.8 ± 735.1 | 2911.3 ± 735.1 | 2454.5 ± 781.3 | 13.3 | <0.01 |
HARS scores | 8.7 ± 5.8 | 8.7 ± 5.1 | 4.0 ± 3.9 | 30.55 | <0.01 |
HDRS scores | 10.1 ± 5.9 | 10.5 ± 4.9 | 3.4 ± 4.2 | 66.92 | <0.01 |